mediator of RNA polymerase II transcription subunit 8; activator-recruited cofactor 32 kD component; ARC32; mediator complex subunit 8 (MED8)

Function: - component of the mediator complex - may play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes & thus in ubiquitination & subsequent proteasomal degradation of target proteins - protein modification; protein ubiquitination - component of an E3 ubiquitin-protein ligase complex with the elongin BC complex (TCEB1 & TCEB2), CUL2 & RBX1 Structure: - the elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV] - belongs to the mediator complex subunit 8 family Compartment: nucleus (probable) Alternative splicing: named isoforms=3

General

phosphoprotein transcription factor (TF)

Properties

SIZE: entity length = 268 aa MW = 29 kD COMPARTMENT: cell nucleus MOTIF: coiled coil {1-28} Ser phosphorylation site {S82} coiled coil {133-163} MOTIF: Elongin BC {142-151}

Database Correlations

OMIM 607956 UniProt Q96G25 Pfam PF10232 Entrez Gene 112950 Kegg hsa:112950

References

UniProt :accession Q96G25