mediator of RNA polymerase II transcription subunit 13; activator-recruited cofactor 250 kD component; ARC250; mediator complex subunit 13; thyroid hormone receptor-associated protein 1; thyroid hormone receptor-associated protein complex 240 kD component; trap240; vitamin D3 receptor-interacting protein complex component DRIP250; DRIP250 (MED13, ARC250, KIAA0593, THRAP1, TRAP240)

Function: - component of the mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase 2- dependent genes Structure: - belongs to the mediator complex subunit 13 family Compartment: nucleus Expression: ubiquitous

General

phosphoprotein transcription factor (TF)

Properties

SIZE: entity length = 2174 aa MW = 239 kD COMPARTMENT: cell nucleus MOTIF: Thr phosphorylation site {T326} Thr phosphorylation site {T329} Thr phosphorylation site {T336} Tyr phosphorylation site {Y394} Ser phosphorylation site {S395} Ser phosphorylation site {S481} Ser phosphorylation site {S500} Ser phosphorylation site {S504} Thr phosphorylation site {T519} Ser phosphorylation site {S530} Ser phosphorylation site {S537} Thr phosphorylation site {T863} Ser phosphorylation site {S890} Ser phosphorylation site {S1029} LXXLL motif 1 {1188-1192} LXXLL motif 2 {1279-1283} serine-rich region {1508-1573} MOTIF: serine residue (SEVERAL) Ser phosphorylation site {S2048}

Database Correlations

OMIM 603808 UniProt Q9UHV7 PFAM correlations Entrez Gene 9969 Kegg hsa:9969

References

UniProt :accession Q9UHV7