mediator of RNA polymerase II transcription subunit 14; activator-recruited cofactor 150 kD component; ARC150; cofactor required for Sp1 transcriptional activation subunit 2; CRSP complex subunit 2; mediator complex subunit 14; RGR1 homolog; hRGR1; thyroid hormone receptor-associated protein complex 170 kD component; trap170; transcriptional coactivator CRSP150; vitamin D3 receptor-interacting protein complex 150 kD component; DRIP150 (MED14, ARC150, CRSP2, CXorf4, DRIP150, EXLM1, RGR1, TRAP170)

Function: - component of the mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase 2- dependent genes - interacts with GATA1 (putative) - interacts with AR, ESR1, SREBF1 & STAT2 Structure: - belongs to the mediator complex subunit 14 family Compartment: nucleus (probable) Expression: ubiquitous

General

phosphoprotein transcription factor (TF)

Properties

SIZE: entity length = 1454 aa MW = 161 kD COMPARTMENT: cell nucleus MOTIF: LXXLL motif 1 {69-73} STAT2 interaction {188-566} SREBF1 interaction {500-824} MOTIF: Ser phosphorylation site {S617} Ser phosphorylation site {S986} proline-rich region SITE: 1002-1165 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S1112} Ser phosphorylation site {S1119} Ser phosphorylation site {S1128} Ser phosphorylation site {S1133} Ser phosphorylation site {S1136} Ser phosphorylation site {S1142} Ser phosphorylation site {S1144} LXXLL motif 2 {1182-1186}

Database Correlations

OMIM 300182 UniProt O60244 Pfam PF08638 Entrez Gene 9282 Kegg hsa:9282

References

UniProt :accession O60244