mediator of RNA polymerase II transcription subunit 23; activator-recruited cofactor 130 kD component; ARC130; cofactor required for Sp1 transcriptional activation subunit 3; CRSP complex subunit 3; mediator complex subunit 23; protein sur-2 homolog; hSur-2; transcriptional coactivator CRSP130; vitamin D3 receptor-interacting protein complex 130 kD component; DRIP130 (MED23, ARC130, CRSP3, DRIP130, KIAA1216, SUR2)

Function: - required for transcriptional activation subsequent to assembly of the preinitiation complex (putative) - component of the mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase 2- dependent genes - required for transcriptional activation by adenovirus E1A protein - required for ELK1-dependent transcriptional activation in response to activated Ras signaling - interacts with ELK1 (putative) - interacts with CEBPB, CTNNB1, & GLI3 - interacts with the adenovirus E1A protein Structure: - belongs to the mediator complex subunit 23 family Compartment: nucleus (probable) Alternative splicing: named isoforms=5

General

phosphoprotein transcription factor (TF)

Properties

SIZE: entity length = 1368 aa MW = 156 kD COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S1352}

Database Correlations

OMIM 605042 UniProt Q9ULK4 Pfam PF11573 Entrez Gene 9439 Kegg hsa:9439

References

UniProt :accession Q9ULK4