mediator of RNA polymerase II transcription subunit 24; activator-recruited cofactor 100 kD component; ARC100; cofactor required for Sp1 transcriptional activation subunit 4; CRSP complex subunit 4; mediator complex subunit 24; thyroid hormone receptor-associated protein 4; thyroid hormone receptor-associated protein complex 100 kD component; trap100; hTRAP100; vitamin D3 receptor-interacting protein complex 100 kD component; DRIP100 (MED24, ARC100, CRSP4, DRIP100, KIAA0130, THRAP4, TRAP100)

Function: - component of the mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase 2- dependent genes - interacts with AR Structure: - belongs to the mediator complex subunit 24 family Compartment: nucleus (probable) Expression: - ubiquitous - abundant in skeletal muscle, heart & placenta

General

phosphoprotein transcription factor (TF)

Properties

SIZE: entity length = 989 aa MW = 110 kD COMPARTMENT: cell nucleus MOTIF: LXXLL motif 1 {128-132} LXXLL motif 2 {344-348} LXXLL motif 3 {448-452} LXXLL motif 4 {557-561} LXXLL motif 5 {788-792} LXXLL motif 6 {857-861} Ser phosphorylation site {S862} Ser phosphorylation site {S873}

Database Correlations

OMIM 607000 UniProt O75448 Pfam PF11277 Entrez Gene 9862 Kegg hsa:9862

References

UniProt :accession O75448