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activating transcription factor 7-interacting protein 2 (MBD1-containing chromatin-associated factor 2, ATF7IP2, MCAF2)
Function:
- recruiter that couples transcriptional factors to general transcription apparatus & thereby modulates transcription regulation & chromatin formation
- can both act as an activator or a repressor depending on the context
- mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1
- complex formed with MBD1 & SETDB1 represses transcription & probably couples DNA methylation & histone Lys-9 trimethylation activity
- interacts with MBD1, SETDB1 & SP1.
- probably forms a complex with SETDB1 & MBD1
Structure:
- belongs to the MCAF family -contains 1 fibronectin F3 module
Compartment: nucleus
Alternative splicing: named isoforms=2
Related
activating transcription factor 7-interacting protein 1 (ATFa-associated modulator, hAM, ATF-IP, ATF-interacting protein, MBD1-containing chromatin-associated factor 1, P621, ATF7IP, MCAF, MCAF1)
General
transcription factor (TF)
Properties
SIZE: MW = 76 kD
entity length = 682 aa
COMPARTMENT: cell nucleus
MOTIF: coiled coil {328-378}
fibronectin type III domain or F3 module {572-674}
Database Correlations
UniProt Q5U623
References
UniProt :accession Q5U623