activating transcription factor 7-interacting protein 1 (ATFa-associated modulator, hAM, ATF-IP, ATF-interacting protein, MBD1-containing chromatin-associated factor 1, P621, ATF7IP, MCAF, MCAF1)

Function: - recruiter that couples transcriptional factors to general transcription apparatus & thereby modulates transcription regulation & chromatin formation - can both act as an activator or a repressor depending on the context - mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 - required to stimulate histone methyltransferase activity of SETDB1 & facilitate the conversion of dimethylated to trimethylated H3 Lys-9 - complex formed with MBD1 & SETDB1 represses transcription & couples DNA methylation & histone Lys-9 trimethylation interacts with MBD1; the interaction is enhanced when MBD1 is sumoylated - probably forms a complex with SETDB1 & MBD1 - interacts with SUMO ubiquitin-like proteins (SUMO1, SUNO2 & SUMO3), with a preference for SUMO2 & SUMO3 - interacts with SP1, ATF7 & ZHX1 Structure: belongs to the MCAF family contains 1 fibronectin F3 module Compartment: nucleus Alternative splicing: named isoforms=3 Pathology: - interacts with Epstein-Barr virus BRLF1/Rta protein, leading to promote & regulate host genes in Epstein- Barr virus- infected cells

General

phosphoprotein transcription factor (TF)

Properties

SIZE: MW = 136 kD entity length = 1270 aa COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S113} glutamate-rich region {349-580} MOTIF: glutamate residue (SEVERAL) Ser phosphorylation site {S477} Ser phosphorylation site {S496} nuclear translocation signal {553-571} SETDB1 interaction {562-817} MOTIF: coiled coil {617-665} Ser phosphorylation site {S673} SUMO interaction {965-975} MBD1 interaction {1154-1270} MOTIF: fibronectin type III domain or F3 module {1157-1261}

References

UniProt :accession Q6VMQ6