activating signal cointegrator 1 complex (ASC-1 complex, TRIP4 complex)

Exists in a steady-state with TRIP4. Structure: - subunits: ASCC1, ASCC2 & ASCC3

General

helicase (DNA unwinding protein, DNA untwisting protein) molecular complex

Properties

COMPARTMENT: cell nucleus MOTIF: DNA-binding motif active site MOTIF: P-loop FOR-BINDING-OF: adenosine triphosphate SUBUNITS: activating signal cointegrator 1 complex subunit 1 COMPARTMENT: cytoplasm MOTIF: KH domain SITE: 86-148 FOR-BINDING-OF: ribonucleic acid activating signal cointegrator 1 complex subunit 2 MOTIF: CUE {467-510} Ser phosphorylation site {S713} activating signal cointegrator 1 complex subunit 3 COMPARTMENT: cytoplasm MOTIF: coiled coil {18-79} Thr phosphorylation site {T234} coiled coil {328-356} helicase NAME: helicase SITE: 486-669 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 499-506 DEVH box {611-614} Helicase C-terminal 1 {728-914} SEC63 1 {978-1287} helicase NAME: helicase SITE: 1336-1511 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 1349-1356 DEAD/H box NAME: DEAD/H box SITE: 1453-1456 Helicase C-terminal 2 {1544-1739} SEC63 2 {1812-1972} SEC63 3 {2103-2177}

References

UniProt :accession Q8N9N2, Q9H1I8, Q8N3C0

Components

activating signal cointegrator 1 complex subunit 1 (ASC-1 complex subunit p50, Trip4 complex subunit p50, ASCC1) activating signal cointegrator 1 complex subunit 2 (ASC-1 complex subunit p100, Trip4 complex subunit p100, ASCC2) activating signal cointegrator 1 complex subunit 3; ASC-1 complex subunit p200; Helicase, ATP binding 1; trip4 complex subunit p200 (ASCC3 HELIC1)