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transcription factor AP-2-delta; AP2-delta; activating enhancer-binding protein 2-delta; transcription factor AP-2-beta-like 1 (TFAP2D, TFAP2BL1)
Function:
- sequence-specific DNA-binding protein
- interacts with inducible viral & cellular enhancer elements to regulate transcription of selected genes
- AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' & activate genes involved in a large spectrum of biological functions including proper eye, face, body wall, limb & neural tube development
- AP-2 factors also suppress a number of genes including MCAM/MUC18, C/EBP alpha & MYC (putative)
- binds DNA as a dimer
- can form homodimers or heterodimers with other AP-2 family members (putative)
Structure: belongs to the AP-2 family
Compartment: nucleus (probable)
Expression:
- expressed in brain, placenta, skeletal muscle, thymus, small intestine, & prostate > leukocyte, spleen, testis, ovary & colon > heart, kidney, liver, lung or pancreas
General
activating protein 2 (AP2)
phosphoprotein
Properties
SIZE: entity length = 452 aa
MW = 50 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S239}
H-S-H (helix-span-helix), dimerization {280-410}
Database Correlations
OMIM 610161
UniProt Q7Z6R9
Pfam PF03299
Entrez Gene 83741
Kegg hsa:83741
References
- UniProt :accession Q7Z6R9
- Wikipedia; Note: activatin protein 2 entry
http://en.wikipedia.org/wiki/activating_protein_2