actin-related protein 3B; actin-like protein 3B; ARP3-beta; actin-related protein ARP4 (ACTR3B, ARP11, ARP4)

Function: - plays a role in the organization of the actin cytoskeleton - may function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization & together with an activating nucleation-promoting factor (NPF) - mediates the formation of branched actin networks - may decrease metastatic potential of tumors - interacts with the Arp2/3 complex composed of ARP2, ARP3, ARPC1B, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC & ARPC5/p16-ARC Structure: belongs to the actin family, ARP3 subfamily Compartment: - cytoplasm, cytoskeleton (putative) - cell projection (putative) Alternative splicing: named isoforms=2 Expression: - detected in fetal brain - detected throughout adult brain, in neurons from gray matter, but not in white matter - detected in liver, skeletal muscle & pancreas - detected in lung adenocarcinoma cells with low metastatic potential, but not in lung adenocarcinoma cells with high metastatic potential

General

cytoskeletal protein phosphoprotein

Properties

SIZE: entity length = 418 aa MW = 48 kD COMPARTMENT: cytoplasm MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Tyr phosphorylation site {Y231} Ser phosphorylation site {S418}

Database Correlations

UniProt Q9P1U1 Pfam PF00022

References

UniProt :accession Q9P1U1