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macrophage-capping protein; actin regulatory protein CAP-G (CAPG AFCP MCP)
Function:
- Ca+2-sensitive protein
- reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments
- may play role in macrophage function
- may play role in regulating cytoplasmic &/or nuclear structures through potential interactions with actin
- may bind DNA
Structure:
- the N-terminus is blocked
- belongs to the villin/gelsolin family
- contains 3 gelsolin-like repeats
Compartment:
- cytoplasm, nucleus
- melanosome, stage 1 to stage 4
Expression: macrophages & macrophage-like cells
Note:
- originally thought to be a DNA-binding protein with a helix-loop-helix domain
General
DNA-binding protein
phosphoprotein
Properties
SIZE: entity length = 348 aa
MW = 39 kD
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: Gelsolin-like {27-75}
nuclear translocation signal {137-146}
Gelsolin-like {148-188}
Gelsolin-like {261-307}
Ser phosphorylation site {S337}
Database Correlations
OMIM 153615
UniProt P40121
Pfam PF00626
Entrez Gene 822
References
UniProt :accession P40121