Search
actin-binding LIM protein 3; abLIM-3; actin-binding LIM protein family member 3 (ABLIM3, KIAA0843, HMFN1661)
Function:
- may act as scaffold protein
- may stimulate ABRA activity & ABRA-dependent SRF transcriptional activity
- directly interacts with F-actin & ABRA
Structure:
- contains 1 HP (headpiece) domain
- contains 4 LIM Zn+2-binding domains
Compartment: cytoplasm (putative)
Alternative splicing: named isoforms=4
Expression:
- expressed predominantly in heart & brain
General
actin-binding LIM protein
Properties
SIZE: entity length = 683 aa
MW = 78 kD
COMPARTMENT: cytoplasm
MOTIF: LIM domain {21-80}
MOTIF: cysteine residue (6)
histidine residue
Zn+2-binding site
LIM domain {80-140}
MOTIF: cysteine residue (6)
histidine residue
Zn+2-binding site
LIM domain {149-208}
MOTIF: cysteine residue (6)
histidine residue
Zn+2-binding site
LIM domain {208-268}
MOTIF: cysteine residue (6)
histidine residue
Zn+2-binding site
Ser phosphorylation site {S277}
Ser phosphorylation site {S280}
Ser phosphorylation site {S282}
Ser phosphorylation site {S372}
Ser phosphorylation site {S373}
Ser phosphorylation site {S388}
Ser phosphorylation site {S394}
Ser phosphorylation site {S503}
Ser phosphorylation site {S504}
villin headpiece domain {615-683}
Database Correlations
OMIM 611305
UniProt O94929
PFAM correlations
Entrez Gene 22885
Kegg hsa:22885
References
UniProt :accession O94929