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actin-binding LIM protein 2; abLIM-2; actin-binding LIM protein family member 2 (ABLIM2, KIAA1808)
Function:
- may act as scaffold protein
- may stimulate ABRA activity & ABRA-dependent SRF transcriptional activity
- interacts with F-actin & ABRA
Structure:
- contains 1 HP (headpiece) domain
- contains 4 LIM Zn+2-binding domains
Compartment:
- cytoplasm
- in skeletal muscle, sarcomeric or cosarcomeric localization (putative)
Alternative splicing: named isoforms=8
Expression: highly expressed in skeletal muscle
General
actin-binding LIM protein
Properties
SIZE: entity length = 611 aa
MW = 68 kD
COMPARTMENT: cytoplasm
MOTIF: LIM domain {22-81}
MOTIF: cysteine residue (6)
histidine residue
Zn+2-binding site
LIM domain {81-141}
MOTIF: cysteine residue (6)
histidine residue
Zn+2-binding site
SITE: 83-83
Zn+2-binding site
SITE: 86-86
Zn+2-binding site
SITE: 103-103
Zn+2-binding site
SITE: 106-106
Zn+2-binding site
SITE: 109-109
Zn+2-binding site
SITE: 112-112
Zn+2-binding site
SITE: 131-131
Zn+2-binding site
SITE: 134-134
LIM domain {151-210}
MOTIF: cysteine residue (6)
histidine residue
Zn+2-binding site
LIM domain {210-270}
MOTIF: cysteine residue (6)
histidine residue
Zn+2-binding site
SITE: 212-212
Zn+2-binding site
SITE: 215-215
Zn+2-binding site
SITE: 232-232
Zn+2-binding site
SITE: 235-235
Zn+2-binding site
SITE: 238-238
Zn+2-binding site
SITE: 241-241
Zn+2-binding site
SITE: 260-260
Zn+2-binding site
SITE: 263-263
Ser phosphorylation site {S289}
Ser phosphorylation site {S294}
Ser phosphorylation site {S296}
Ser phosphorylation site {S476}
villin headpiece domain {543-611}
Database Correlations
OMIM 612544
UniProt Q6H8Q1
PFAM correlations
Entrez Gene 84448
Kegg hsa:84448
References
UniProt :accession Q6H8Q1