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actin-binding LIM protein 1; abLIM-1; actin-binding LIM protein family member 1; actin-binding double zinc finger protein; LIMAB1; Limatin (ABLIM1, ABLIM, KIAA0059, LIMAB1)
Function:
- may act as scaffold protein
- may play a role in the development of the retina
- may play a role in axon guidance
- phosphorylated upon DNA damage, probably by ATM or ATR
- binds F-actin
- interacts with ABRA
Structure:
- contains 1 HP (headpiece) domain
- contains 4 LIM Zn+2-binding domains
Compartment:
- cytoplasm, cytoskeleton
- associated with the cytoskeleton (putative)
Alternative splicing: named isoforms=5
Expression:
- detected in liver, heart, skeletal muscle, brain & retina
- in the retina, concentrated in the inner segment & in the outer plexiform layers
General
actin-binding LIM protein
phosphoprotein
Properties
SIZE: entity length = 778 aa
MW = 88 kD
COMPARTMENT: cytoplasm
MOTIF: LIM domain {97-156}
MOTIF: cysteine residue (6)
histidine residue
Zn+2-binding site
LIM domain {156-216}
MOTIF: cysteine residue (6)
histidine residue
Zn+2-binding site
Ser phosphorylation site {S216}
LIM domain {224-283}
MOTIF: cysteine residue (6)
histidine residue
Zn+2-binding site
LIM domain {283-343}
MOTIF: cysteine residue (6)
histidine residue
Zn+2-binding site
Ser phosphorylation site {S353}
Tyr phosphorylation site {Y357}
Ser phosphorylation site {S367}
Tyr phosphorylation site {Y373}
Tyr phosphorylation site {Y396}
Tyr phosphorylation site {Y406}
Tyr phosphorylation site {Y410}
Ser phosphorylation site {S426}
Thr phosphorylation site {T429}
Ser phosphorylation site {S431}
Thr phosphorylation site {T433}
Ser phosphorylation site {S435}
Tyr phosphorylation site {Y439}
Ser phosphorylation site {S450}
Thr phosphorylation site {T451}
Ser phosphorylation site {S452}
Ser phosphorylation site {S455}
Ser phosphorylation site {S458}
Tyr phosphorylation site {Y461}
Ser phosphorylation site {S473}
Ser phosphorylation site {S587}
coiled coil {590-614}
Ser phosphorylation site {S640}
Ser phosphorylation site {S655}
Ser phosphorylation site {S706}
villin headpiece domain {710-778}
Database Correlations
OMIM 602330
UniProt O14639
PFAM correlations
Entrez Gene 3983
Kegg hsa:3983
References
UniProt :accession O14639