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adrenocorticotropic hormone receptor; ACTH receptor; ACTH-R; adrenocorticotropin receptor; melanocortin receptor 2; MC2-R (MC2R ACTHR)
Function:
- receptor for ACTH
- activity mediated by G proteins (Gs protein) which activate adenylate cyclase
- interacts with FALP/MRAP
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Expression: melanocytes & corticoadrenal tissue
Pathology:
- defects in MC2R are the cause of glucocorticoid deficiency type 1
Interactions
molecular events
Related
adrenocorticotropic hormone; corticotropin; adrenocorticotropin (ACTH)
General
melanocortin receptor
Properties
SIZE: entity length = 297 aa
MW = 34 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-23}
MOTIF: N-glycosylation site {N12}
N-glycosylation site {N17}
transmembrane domain {24-49}
cytoplasmic loop {50-58}
transmembrane domain {59-79}
exoplasmic loop {80-104}
transmembrane domain {105-126}
cytoplasmic loop {127-147}
transmembrane domain {148-168}
exoplasmic loop {169-180}
transmembrane domain {181-199}
cytoplasmic loop {200-217}
transmembrane domain {218-244}
exoplasmic loop {245-256}
transmembrane domain {257-278}
cytoplasmic domain {279-297}
MOTIF: cysteine residue {C293}
MODIFICATION: palmitate
COMPARTMENT: membrane
Database Correlations
OMIM correlations
UniProt Q01718
Pfam PF00001
Entrez Gene 4158
Kegg hsa:4158
References
- UniProt :accession Q01718
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=MC2R
- Cozza EN et al
ACTH increases de novo synthesis of diacylglycerol and
translocates protein kinase C in primary cultures of calf
adrenal glomerulosa cells.
J Steroid Biochem. 1990 Feb;35(2):343-51.
PMID: 2155356
- Entrez Gene :accession 4158