acrosome formation-associated factor; equatorin (AFAF, EQTN, C9orf11)

Function: - role in acrosome biogenesis (putative) - role in fertilization of ovum - interacts with SNAP25 Structure: - highly N-glycosylated & O-glycosylated - contains sialic acid Compartment: - acrosome membrane, membrane - cytoplasmic vesicle, secretory vesicle - single-pass type 1 membrane protein Alternative splicing: named isoforms=3 Expression: - isoform 1 highly expressed in testis - isoform 2 is expressed at low levels in skin & blood

General

glycoprotein human longevity protein membrane protein

Properties

SIZE: MW = 33 kD entity length = 294 aa COMPARTMENT: cellular membrane MOTIF: signal sequence {1-14} Vesicular {15-181} MOTIF: N-glycosylation site {N76} N-glycosylation site {N143} transmembrane domain {182-202}

Database Correlations

UniProt Q9NQ60 Pfam PF15339 Entrez Gene 54586 Kegg hsa:54586

References

UniProt :accession Q9NQ60