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acrosin-binding protein (acrosin-binding protein sp32, cancer testis antigen OY-TES-1, ACRBP)
Function:
1) role in packaging & condensation of acrosin zymogen in acrosomal matrix via its association with acrosin (proacrosin)
2) binds acrosin (proacrosin)
3) phosphorylated on Tyr residues in capacitated sperm
Structure:
- N-terminus is blocked
Compartment:
- secreted, acrosome
- colocalizes with acrosin (proacrosin) in acrosome of sperm
Expression: restricted to testis in normal tissue
Pathology:
- expressed in a wide spectrum of cancers, including bladder cancer, breast cancer, liver cancer, lung cancer & colon cancer
Related
acrosin ([contains: acrosin light chain; Acrosin heavy chain], ACR, ACRS)
General
secreted protein
Properties
SIZE: MW = 61 kD
entity length = 543 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-25}
Database Correlations
OMIM 608352
UniProt Q8NEB7
Pfam PF07222
References
UniProt :accession Q8NEB7