Search
aconitate hydratase, mitochondrial (citrate hydro-lyase, aconitase-2, ACO2)
Function:
- carbohydrate metabolism; tricarboxylic acid cycle
- converts citrate to isocitrate via cis-aconitate
- inhibited by chloroacetate
citrate isocitrate
Cofactor:
- binds 1 4Fe-4S cluster per subunit. binding of a 3Fe-4S cluster leads to an inactive enzyme (putative)
Structure:
- monomer (putative)
- belongs to the aconitase/IPM isomerase family
Compartment: mitochondrial matrix (putative)
Interactions
molecular events
Related
citric acid cycle, Krebs cycle or tricarboxylic acid [TCA] cycle
General
aconitase, aconitate-hydratase or citrate hydrolyase
citric acid cycle enzyme
Properties
SIZE: entity length = 780 aa
MW = 85 kD
COMPARTMENT: mitochondrial matrix
MOTIF: cofactor-binding site [385-385]
COFACTOR-BOUND: iron sulfur [FeS] cluster
cofactor-binding site [448-448]
COFACTOR-BOUND: iron sulfur [FeS] cluster
cofactor-binding site [451-451]
COFACTOR-BOUND: iron sulfur [FeS] cluster
Database Correlations
OMIM 100850
UniProt Q99798
PFAM correlations
Entrez Gene 50
Kegg hsa:50;
ENZYME 4.2.1.3
References
- Wikipedia; aconitase entry
http://en.wikipedia.org/wiki/Aconitase
- UniProt :accession Q99798