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acid phosphatase-5 (tartrate-resistant acid phosphatase, TRAP, TrATPase, ACP5)
Function:
phosphate monoester + H2O an alcohol + phosphate
Cofactor: binds 2 Fe+2/Fe+3 per subunit
Pathology:
- normally minor intracellular isozyme of acid phosphatase; can become dominant isozyme in Gaucher's disease, Hodgkin's disease, hairy cell leukemia
General
acid phosphatase
glycoprotein
metalloprotein
Properties
SIZE: entity length = 325 aa
MW = 37 kD
COMPARTMENT: lysosome
MOTIF: signal sequence {1-21}
Iron [Fe]-binding site
SITE: 33-33
Iron [Fe]-binding site
SITE: 71-71
Iron [Fe]-binding site
SITE: 74-74
Iron [Fe]-binding site
SITE: 110-110
N-glycosylation site {N116}
N-glycosylation site {N147}
cysteine residue {C161}
MODIFICATION: cysteine residue {C219}
Iron [Fe]-binding site
SITE: 205-205
cysteine residue {C219}
MODIFICATION: cysteine residue {C161}
Iron [Fe]-binding site
SITE: 240-240
Iron [Fe]-binding site
SITE: 242-242
Database Correlations
OMIM 171640
UniProt P13686
Pfam PF00149
Entrez Gene 54
ENZYME 3.1.3.2
References
UniProt :accession P13686