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acidic leucine-rich nuclear phosphoprotein 32 member E; LANP-like protein (ANP32E, LANP-L)
Function:
- histone chaperone
- specifically mediates the genome-wide removal of histone H2A.Z/H2AFZ from the nucleosome
- removes H2A.Z/H2AFZ from its normal sites of deposition, especially from enhancer & insulator regions
- not involved in deposition of H2A.Z/H2AFZ in the nucleosome
- may stabilize the evicted H2A.Z/H2AFZ-H2B dimer, thus driving dissociation & the off-chromatin state
- inhibits activity of protein phosphatase 2A
- does not inhibit protein phosphatase 1
- cerebellar development (putative)
- phosphorylated
- phosphorylation is nuclear localization signal (NLS- dependent) (putative)
- interacts with the importin alpha KPNA1 & KPNA2
- component of a SWR1-like complex, composed of EP400, KAT5/TIP60, TRRAP, BRD8, RUVBL1, RUVBL2, ING3 & ANP32E
- the complex does not contain SRCAP
Structure:
- the H2A.Z-interacting domain (ZID) mediates a direct interaction with H2A.Z/H2AFZ
- belongs to the ANP32 family,
- contains 4 LRR repeats (leucine-rich repeats)
- contains 1 LRRCT domain
Compartment:
- cytoplasm, nucleus
Alternative splicing: named isoforms=3
Expression:
- expressed in peripheral blood leukocytes, colon, small intestine, prostate, thymus, spleen, skeletal muscle, liver, kidney
General
acidic leucine-rich nuclear phosphoprotein 32 (ANP32)
Properties
SIZE: MW = 31 kD
entity length = 268 aa
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
leucine-rich repeat
SITE: 18-38
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 43-64
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 65-87
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 89-110
MOTIF: leucine residue (SEVERAL)
LRRCT {123-161}
acidic region {151-266}
MOTIF: acidic residue (SEVERAL)
Ser phosphorylation site {S158}
ZID {215-268}
Database Correlations
OMIM 609611
UniProt Q9BTT0
Pfam PF12799
Entrez Gene 81611
Kegg hsa:81611
References
- UniProt :accession Q9BTT0
- Obri A, Ouararhni K, Papin C et al
ANP32E is a histone chaperone that removes H2A.Z from chromatin.
Nature. 2014 Jan 30;505(7485):648-53.
PMID: 24463511