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acidic leucine-rich nuclear phosphoprotein 32 member C; phosphoprotein 32-related protein 1; tumorigenic protein pp32r1 (ANP32C, PP32R1)
Structure:
- belongs to the ANP32 family
- contains 4 LRR repeats (leucine-rich repeats)
- although classified as a phosphoprotein, no phosphorylation sites are identified
Expression:
- expressed in activated stem cells, such as mobilized CD34+ cells & cord blood CD34+ cells, but not in resting bone marrow CD34+ cells
- expressed in a variety of neoplastic cell lines, mainly in prostatic adenocarcinoma cell lines
- not expressed in normal prostatic tissue
Note:
- His-140 polymorphism is uncertain
General
acidic leucine-rich nuclear phosphoprotein 32 (ANP32)
Properties
SIZE: entity length = 234 aa
MW = 27 kD
COMPARTMENT: cell nucleus
MOTIF: leucine-rich repeat
SITE: 44-63
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 64-84
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 85-107
MOTIF: leucine residue (SEVERAL)
phosphorylation site
leucine-rich repeat
SITE: 111-134
MOTIF: leucine residue (SEVERAL)
acidic region {157-228}
MOTIF: acidic residue (SEVERAL)
Database Correlations
OMIM 606877
UniProt O43423
Pfam PF12799
Entrez Gene 23520
Kegg hsa:23520
References
UniProt :accession O43423