acidic leucine-rich nuclear phosphoprotein 32 member B; PHAPI2 protein; silver-stainable protein SSP29; acidic protein rich in leucines; HLA-DR-associated protein I-2 (ANP32B, APRIL, PHAPI2)

Function: - multifunctional protein - cell cycle progression factor - cell survival factor - required for progression from G1 to S phase - anti-apoptotic protein - functions as a caspase-3 inhibitor - has no phosphatase 2A (PP2A) inhibitor activity (putative) - has histone chaperone properties - stimulates core histones to assemble into a nucleosome - some glutamate residues are glycylated by TTLL8 - glycylation occurs exclusively on glutamate residues & results in a glycine chain on the gamma-carboxyl group (putative) - interacts with histones H3 & H4 Structure: - monomer - histone binding is mediated by the concave surface of the LRR region - belongs to the ANP32 family, - contains 4 LRR repeats (leucine-rich repeats) - contains 1 LRRCT domain Compartment: - isoform 1: nucleus; accumulates in nuclei in S phase - isoform 2: cytoplasm; lacks a nuclear localization signal Alternative splicing: named isoforms=2 Expression: - expressed in heart, lung, pancreas, prostate & in spleen, thymus & placenta

Properties

SIZE: MW = 29 kD entity length = 251 aa COMPARTMENT: cytoplasm cell nucleus MOTIF: leucine-rich repeat SITE: 16-40 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 43-64 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 65-84 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 89-110 MOTIF: leucine residue (SEVERAL) LRRCT {123-161} acidic region {146-251} MOTIF: acidic residue (SEVERAL) Thr phosphorylation site {T244}

Database Correlations

UniProt Q92688 Entrez Gene 10541 Kegg hsa:10541

References

UniProt :accession Q92688