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acidic fibroblast growth factor intracellular binding protein; aFGF intracellular binding protein; FGF-1 intracellular binding protein (FIBP)
Function:
1) may be involved in mitogenic function of FGF1
2) binds to internalized FGF1
- interaction is increased in the presence of CSNKB
Compartment:
- nucleus, intracellular membrane; peripheral membrane cytoplasmic membranes, mitochondrial membrane
Alternative splicing: named isoforms=2
Expression:
- expressed in heart, skeletal muscle, pancreas > brain, placenta, liver, kidney
General
nuclear protein
Properties
SIZE: MW = 42 kD
entity length = 364 aa
COMPARTMENT: mitochondria
cytoplasm
cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Database Correlations
OMIM 608296
UniProt O43427
Pfam PF05427
Entrez Gene 9158
Kegg hsa:9158
References
- UniProt :accession O43427
- NIEHS-SNPs
http://egp.gs.washington.edu/data/fibp/