calponin-3; calponin, acidic isoform (CNN3)

Function: - thin filament-associated protein implicated in regulation & modulation of smooth muscle contraction - capable of binding to actin, calmodulin, troponin C & tropomyosin - interaction of calponin with actin inhibits actomyosin Mg-ATPase activity Structure: - belongs to the calponin family - contains 3 calponin-like repeats - contains 1 CH (calponin-homology) domain Expression: - expressed in smooth muscle & other tissues

General

calponin phosphoprotein

Properties

SIZE: entity length = 329 aa MW = 36 kD COMPARTMENT: cytoplasm MOTIF: calponin homology domain NAME: calponin homology domain SITE: 26-129 Calponin-like {164-189} Calponin-like {204-229} Calponin-like {243-268} MOTIF: Ser phosphorylation site {S244} Tyr phosphorylation site {Y261} acidic region {290-329} MOTIF: acidic residue (SEVERAL) Ser phosphorylation site {S323}

Database Correlations

OMIM 602374 UniProt Q15417 PFAM correlations Entrez Gene 1266 Kegg hsa:1266

References

UniProt :accession Q15417