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acellular Pertussis vaccine (Repevax)

Indications: - children > 2 years of age, adolescents & adults - pregnant women, at end of 2nd trimester or in 3rd trimester [4] Dosage: - 5 doses of the vaccine by age 4-6 years & a booster between 11-12 years are currently recommended Complications: - no increased risk of complications when administerd in the 3rd trimester of pregnancy [9] Notes: - children fully vaccinated against pertussis are still at risk, which increases with time since immunization [10] - 92% effective [1] (seems in conflict with ref [8]) - effectiveness may diminish within 3 years [5] - fully vaccinated children 5-fold more susceptible to pertussis 3 years after vaccination [11] - among fully vaccinated children (total of 4 doses), vaccine efficacy decreases from 98.1% within the first year of the final dose to 71.2% after 60 months [7] - among children with persistent cough, evidence of recent pertussis found in 18% of fully vaccinated children (vs 20% of children overall) [8] - the original pertussis vaccine, derived from the cellular components of Bordetella pertussis in the 1940s, was highly effective but caused adverse side effects (fever, febrile seizures) [11] - in the 1990s, it was replaced with a less reactogenic acellular pertussis vaccine. - outbreaks still seen despite 6 vaccinations & mandagory vaccination policies

Related

acellular pertussis vaccine/diphtheria toxoid/tetanus toxoid; diphtheria, tetanus toxoid & pertussis vaccine (DPT, DTaP, TDaP, DTP, Acel-Immune, Tri-Immunol, Tripedia, Daptacel, INFANRIX, Adacel, Boostrix) diphtheria, tetanus toxoid, pertussis & haemophilus b vaccine (Tetramune, DTP-Hib)

General

vaccine

References

  1. Ward JI, Cherry JD, Chang SJ, Partridge S, Lee H, Treanor J, Greenberg DP, Keitel W, Barenkamp S, Bernstein DI, Edelman R, Edwards K; APERT Study Group. Efficacy of an acellular pertussis vaccine among adolescents and adults. N Engl J Med. 2005 Oct 13;353(15):1555-63. PMID: 16221778 - Halperin SA. Pertussis--a disease and vaccine for all ages. N Engl J Med. 2005 Oct 13;353(15):1615-7. No abstract available. PMID: 16221785
  2. Zepp F et al, Safety of reduced-antigen-content tetanus-diptheria acellular pertussis vaccine in adolescents as a sixth consecutive dose of acellular pertussis-containing vaccine. J Pediatr 2006, 149:603 PMID: 17095328 - Haperin SA Recommendation for an adolescent dose of tetanus and diphtheria toxoids and acellular pertussis vaccine: Reassurance for the future. J Pediatr 2006, 149:589 PMID: 17095321
  3. Prescriber's Letter 14(2): 2007 Adult and Pediatric Immunization Update - 2007 Detail-Document#: 230209 (subscription needed) http://www.prescribersletter.com
  4. The Washington Post Federal panel recommends vaccinating pregnant women to protect infants from whooping cough http://www.washingtonpost.com/national/health-science/federal-panel-recommends-vaccinating-pregnant-women-to-protect-infants-from-whooping-cough/2011/06/22/AG3EvGgH_story.html
  5. Associated Press, Sept 19, 2011 http://articles.boston.com/2011-09-19/lifestyle/30176444_1_whooping-cough-booster-shot-highly-contagious-bacterial-disease
  6. Associated Press: February 22 All older adults added to vaccine advice for whooping cough by US advisory panel Washington Post http://www.washingtonpost.com/national/health-science/all-older-adults-should-get-vaccinated-against-whooping-cough-us-advisory-panel-says/2012/02/22/gIQAiEsLTR_story.html
  7. Misegades LK et al. Association of childhood pertussis with receipt of 5 doses of pertussis vaccine by time since last vaccine dose, California, 2010. JAMA 2012 Nov 28; 308:2126. PMID: 23188029
  8. Wang K, Fry NK, Campbell H et al Whooping cough in school age children presenting with persistent cough in UK primary care after introduction of the preschool pertussis booster vaccination: prospective cohort study. BMJ 2014;348:g3668 PMID: 24961836 http://www.bmj.com/content/348/bmj.g3668
  9. Donegan K et al Safety of pertussis vaccination in pregnant women in UK: observational study. BMJ 2014;349:g4219 PMID: 25015137 http://www.bmj.com/content/349/bmj.g4219
  10. Zerbo O, Bartlett J, Goddard K et al. Acellular pertussis vaccine effectiveness over time. Pediatrics 2019 Jun 10 PMID: 31182549 https://pediatrics.aappublications.org/content/early/2019/06/06/peds.2018-3466
  11. Centers for Disease Control and Prevention (CDC) Pertussis (Whooping Cough) Vaccination http://www.cdc.gov/vaccines/vpd-vac/pertussis/

Component-of

acellular pertussis vaccine/diphtheria toxoid/haemophilus B vaccine/hepatitis B vaccine/poliovirus inactivated vaccine/tetanus toxoid (DtaP-HepB-IPV) acellular pertussis vaccine/diphtheria toxoid/hepatitis B vaccine/poliovirus inactivated vaccine/tetanus toxoid (DtaP-HepB-IPV) acellular pertussis vaccine/diphtheria toxoid/poliovirus vaccine inactivated/tetanus toxoid (Quadracel, DTaP-IPV, Kinrix) acellular pertussis vaccine/diphtheria toxoid/tetanus toxoid; diphtheria, tetanus toxoid & pertussis vaccine (DPT, DTaP, TDaP, DTP, Acel-Immune, Tri-Immunol, Tripedia, Daptacel, INFANRIX, Adacel, Boostrix) acellular pertussis vaccine/hepatitis b surface antigen/hepatitis b vaccine/poliovirus vaccine inactivated/tetanus toxoid acellular pertussis vaccine/poliovirus vaccine inactivated/tetanus toxoid acellular pertussis vaccine/tetanus toxoid