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Abl interactor 1; Abelson interactor 1; Abi-1; Abl-binding protein 4; AblBP4; eps8 SH3 domain-binding protein; eps8-binding protein; Nap1-binding protein; Nap1BP; spectrin SH3 domain-binding protein 1; e3B1 (ABI1, SSH3BP1)

Function: 1) negative regulation of cell growth & transformation 2) interacts with nonreceptor tyrosine kinases ABL1 &/or ABL2 3) regulation of EGF-induced Erk pathway activation 4) cytoskeletal reorganization & EGFR signaling 5) transduction of signals from Ras to Rac in association with EPS8 a) trimeric complex of ABI1, EPS8, SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity b) ABI1 acts as an adapter in the complex 6) regulates ABL1-mediated phosphorylation of MENA 7) recruits WASF1 to lamellipodia 8) regulates WASF1 protein level 9) interacts with ABL1, MENA, STX1A, SNAP25, VAMP2, EPS8, WASF1, SOS1, SOS2, GRB2, SPTA1, NCKAP1, NCK1 (+/-) 10) in vitro substrate for v-Abl 11) phosphorylated on Tyr after induction by v-Abl 12) component of complex consisting of ABI1, STX1A, SNAP25 13) component complex consisting of ABI1, EPS8, SOS1 14) component of the WAVE2 complex Structure: - the t-SNARE coiled-coil homology domain is necessary & sufficient for interaction with STX1A (putative) - belongs to the ABI family - contains 1 SH3 domain - contains 1 t-SNARE coiled-coil homology domain Compartment: - cytoplasm, nucleus - localized to protruding lamellipodia & filopodia tips - localized to neuronal growth cones & synaptosomes Alternative splicing: named isoforms=11 Expression: - widely expressed - highest expression in brain Pathology: - chromosomal translocation t(10;11)(p11.2;q23) involving ABI1 & MLL associated with acute leukemia

Related

Abl interactor 1 (ABI1) gene

General

nuclear protein phosphoprotein SH3 domain-binding protein

Properties

SIZE: entity length = 508 aa MW = 55 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl binding to WASF1 {18-79} SNARE motif {45-107} MOTIF: breakpoint {95-96} Ser phosphorylation site {S183} Tyr phosphorylation site {Y213} Ser phosphorylation site {S216} Ser phosphorylation site {S222} Ser phosphorylation site {S225} proline-rich region SITE: 260-418 MOTIF: proline residue (SEVERAL) Tyr phosphorylation site {Y333} src homology 3 [SH3] domain SITE: 446-505 MOTIF: Tyr phosphorylation site {Y455}

Database Correlations

OMIM 603050 UniProt Q8IZP0 PFAM correlations Entrez Gene 10006 Kegg hsa:10006

References

  1. UniProt :accession Q8IZP0
  2. Atlas of Genetics & Cytogenetics in Oncology & Haematology http://atlasgeneticsoncology.org/genes/ABI1ID233.html

Component-of

WAVE2 complex