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ABI1/EPS8/SOS1 complex
Function:
1) transduction of signals from Ras to Rac
2) exhibits Rac specific guanine nucleotide exchange factor (GEF) activity
3) ABI1 act as an adapter in the complex
Structure:
- consists of ABI1, EPS8, SOS1
General
guanine nucleotide exchange factor (GDP/GTP dissociation stimulator, guanine nucleotide-releasing factor/protein, GNEF, GNDS, GDS)
molecular complex
Properties
COMPARTMENT: cell nucleus
MOTIF: guanine nucleotide exchange domain
NAME: guanine nucleotide exchange domain
SUBUNITS: Abl interactor 1
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
binding to WASF1 {18-79}
SNARE motif {45-107}
MOTIF: breakpoint {95-96}
Ser phosphorylation site {S183}
Tyr phosphorylation site {Y213}
Ser phosphorylation site {S216}
Ser phosphorylation site {S222}
Ser phosphorylation site {S225}
proline-rich region
SITE: 260-418
MOTIF: proline residue (SEVERAL)
Tyr phosphorylation site {Y333}
src homology 3 [SH3] domain
SITE: 446-505
MOTIF: Tyr phosphorylation site {Y455}
epidermal growth factor receptor kinase substrate 8
MOTIF: PH; first part {69-129}
PH; second part {381-414}
proline-rich region
SITE: 421-440
MOTIF: proline residue (SEVERAL)
Tyr phosphorylation site {Y485}
Tyr phosphorylation site {Y525}
src homology 3 [SH3] domain
SITE: 531-590
proline-rich region
SITE: 615-651
MOTIF: proline residue (SEVERAL)
serine-rich region {659-664}
MOTIF: serine residue (SEVERAL)
Ser phosphorylation site {S659}
Ser phosphorylation site {S661}
Ser phosphorylation site {S662}
Tyr phosphorylation site {Y774}
Ser phosphorylation site {S811}
Ser phosphorylation site {S815}
Sos1 protein
MOTIF: Dbl homology domain {200-390}
PH domain {444-548}
guanine nucleotide exchange domain
NAME: guanine nucleotide exchange domain
SITE: 597-741
guanine nucleotide exchange domain
NAME: guanine nucleotide exchange domain
SITE: 780-1019
Ser phosphorylation site {S1043}
Ser phosphorylation site {S1078}
Ser phosphorylation site {S1082}
Ser phosphorylation site {S1210}
proline-rich region
SITE: 1258-1261
FOR-BINDING-OF: growth factor receptor-bound protein-2 (grb2)
RAS-GNRP-C3G
MOTIF: proline residue (SEVERAL)
References
UniProt :accession Q8IZP0
Components
Abl interactor 1; Abelson interactor 1; Abi-1; Abl-binding protein 4; AblBP4; eps8 SH3 domain-binding protein; eps8-binding protein; Nap1-binding protein; Nap1BP; spectrin SH3 domain-binding protein 1; e3B1 (ABI1, SSH3BP1)
epidermal growth factor receptor kinase substrate 8 (EPS8)
son of sevenless homolog protein 1 (Sos1)