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abarelix (Plenaxis)
Tradename: Plenaxis
Indications:
-> advanced prostate cancer
Adverse effects:
1) allergic reactions (life-threatening) 4%
2) hot flashes
3) insomnia
4) constipation
5) gynecomastia
6) mastodynia
Mechanism of action:
1) blocks gonadotropin-releasing hormone receptors
2) does not cause initial testosterone surge like Lupron
General
antineoplastic agent (chemotherapeutic agent)
References
Prescriber's Letter 11(1):1 2004
Detail-Document#: 200104
(subscription needed) http://www.prescribersletter.com