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7S nerve growth factor (7S NGF)
NGF beta subunit contains all growth-promoting activity.
Interactions
molecular events
Related
CD271; p75 NGFR; tumor necrosis factor receptor superfamily member 16; low-affinity nerve growth factor receptor; NGF receptor; Gp80-LNGFR; p75 ICD; low affinity neurotrophin receptor p75NTR (NGFR, TNFRSF16)
nerve growth factor topical (NGF topical)
nerve growth factor [NGF] receptor (high affinity)
General
molecular complex
neurotrophic factor or neurotrophin
Properties
SIZE: MW = 130 kD
COMPARTMENT: extracellular compartment
SUBUNITS: nerve growth factor [NGF]-alpha
CONFIGURATION: dimer
nerve growth factor-beta
CONFIGURATION: dimer
MOTIF: signal sequence {1-18}
N-glycosylation site {N69}
Ser phosphorylation site {S84}
N-glycosylation site {N114}
cysteine residue {C136}
MODIFICATION: cysteine residue {C201}
cysteine residue {C179}
MODIFICATION: cysteine residue {C229}
cysteine residue {C189}
MODIFICATION: cysteine residue {C231}
cysteine residue {C201}
MODIFICATION: cysteine residue {C136}
cysteine residue {C229}
MODIFICATION: cysteine residue {C179}
cysteine residue {C231}
MODIFICATION: cysteine residue {C189}
nerve growth factor [NGF]-gamma
CONFIGURATION: dimer
MOTIF: charge relay system
MOTIF: aspartate residue
histidine residue
serine residue
Database Correlations
Kegg hsa/hsa04210
References
Dreyfus TIPS 1990 July 10(4):145-149
Components
nerve growth factor [NGF]-alpha or 7S NGF acidic subunit
nerve growth factor [NGF]-beta (NGFB)
nerve growth factor [NGF]-gamma