5-hydroxytryptamine receptor 3E (serotonin receptor 3E, 5-HT3E, HTR3E)

Function: - one of several different receptors for 5-hydroxytryptamine (serotonin) - ligand-gated ion channel, which when activated causes fast, depolarizing responses - cation-specific, but otherwise relatively nonselective, ion channel - forms a pentaheteromeric complex with HTR3A, homomeric complex being not functional Structure: - belongs to the ligand-gated ionic channel (TC 1.A.9) family Compartment: - cell membrane - presumably retained within the endoplasmic reticulum unless complexed with HTR3A Alternative splicing: named isoforms=5 Expression: expressed in adult colon & intestine

General

glycoprotein serotonin [5HT]-3 receptor transmembrane 4e protein

Properties

SIZE: entity length = 456 aa MW = 51 kD COMPARTMENT: endoplasmic reticulum MOTIF: exoplasmic domain {1-248} MOTIF: signal sequence {1-25} cysteine residue {C162} MODIFICATION: cysteine residue {C176} N-glycosylation site {N175} cysteine residue {C176} MODIFICATION: cysteine residue {C162} transmembrane domain {249-269} cytoplasmic loop {270-282} transmembrane domain {283-303} exoplasmic loop {304-307} transmembrane domain {308-328} cytoplasmic loop {329-433} transmembrane domain {434-454} exoplasmic domain {455-456}

Database Correlations

UniProt A5X5Y0 PFAM correlations

References

UniProt :accession A5X5Y0