5-hydroxytryptamine receptor 3D (serotonin receptor 3D, 5-HT3D, HTR3D)

Function: - one of several different receptors for 5-hydroxytryptamine (serotonin) - ligand-gated ion channel, which when activated causes fast, depolarizing responses - cation-specific, but otherwise relatively nonselective, ion channel - forms a pentaheteromeric complex with HTR3A, homomeric complex being not functional Structure: - belongs to the ligand-gated ionic channel (TC 1.A.9) family Compartment: - cell membrane - presumably retained within the endoplasmic reticulum unless complexed with HTR3A Alternative splicing: named isoforms=3 Expression: - expressed in liver, & fetal & adult colon & kidney

General

glycoprotein serotonin [5HT]-3 receptor transmembrane 4e protein

Properties

SIZE: entity length = 454 aa MW = 50 kD COMPARTMENT: endoplasmic reticulum MOTIF: exoplasmic domain {1-232} MOTIF: signal sequence {1-24} N-glycosylation site {N66} transmembrane domain {233-253} cytoplasmic loop {254-264} transmembrane domain {265-285} exoplasmic loop {286-306} transmembrane domain {307-327} cytoplasmic loop {328-431} transmembrane domain {432-452} exoplasmic domain {453-454}

Database Correlations

UniProt Q70Z44 PFAM correlations Entrez Gene 9177

References

UniProt :accession Q70Z44