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5-formyltetrahydrofolate cyclo-ligase; 5,10-methenyl-tetrahydrofolate synthetase; methenyl-THF synthetase (MTHFS)
Function:
ATP + 5-formyltetrahydrofolate
ADP + phosphate + 5,10-methenyltetrahydrofolate
Cofactor: Mg+2
Structure:
- monomer
- belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Compartment: cytoplasm
General
ligase or synthetase
Properties
SIZE: entity length = 203 aa
MW = 23 kD
COMPARTMENT: cytoplasm
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
binding site
SITE: 18-18
FOR-BINDING-OF: Folate
active site
Database Correlations
OMIM 604197
UniProt P49914
Pfam PF01812
Entrez Gene 10588
Kegg hsa:10588
References
UniProt :accession P49914