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5-aminosalicylate (5-ASA)
Indications:
- treatment of inflammatory bowel disease
Adverse effects:
1) fewer side effect than with sulfasalazine
2) diarrhea is most common side effect
3) interstitial nephritis (rare) [3]
Interactions
drug interactions
drug adverse effects of NSAIDs
monitor with non steroidal anti-inflammatory agents (NSIADs)
Specific
balsalazide (Colazal, Giazo)
mesalamine (Asacol, Rowasa, Pentasa, Pentasacaps, Lialda, Apriso, Canasa, Delzicol)
olsalazine (Dipentum)
sulfasalazine (SSZ, Azulfidine, SAS)
General
gastrointestinal agent
salicylate
Properties
INHIBITS: cyclooxygenase
Database Correlations
PUBCHEM correlations
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Manual of Medical Therapeutics, 28th ed, Ewald &
McKenzie (eds), Little, Brown & Co, Boston, 1995, pg 356.
- Medical Knowledge Self Assessment Program (MKSAP) 16
American College of Physicians, Philadelphia 2012