actin-like protein 6A; 53 kD BRG1-associated factor A; actin-related protein Baf53a; ArpNbeta; BRG1-associated factor 53A; BAF53A; INO80 complex subunit K (ACTL6A, BAF53, BAF53A, INO80K)

Function: - role in transcriptional activation & repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology) - required for maximal ATPase activity of SMARCA4 & for association of the SMARCA4-containing remodeling BAF complex with chromatin/nuclear matrix - component of the npBAF complex & is required for the proliferation of neural progenitors - component of the NuA4 histone acetyltransferase complex (HAT complex) - also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex - component of numerous complexes with chromatin remodeling & histone acetyltransferase activity - component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 & YEATS4/GAS41 - component of the BAF complex - component of the BAF53 complex - component of the chromatin-remodeling INO80 complex - component of the WINAC complex - component of the npBAF complex - interacts with PHF10/BAF45A (putative) Structure: belongs to the actin family Compartment: nucleus Alternative splicing: named isoforms=2

General

cytoskeletal protein nuclear protein phosphoprotein

Properties

SIZE: entity length = 429 aa MW = 47 kD COMPARTMENT: cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Ser phosphorylation site {S233}

Database Correlations

OMIM 604958 UniProt O96019 Pfam PF00022 Entrez Gene 86 Kegg hsa:86; -.

References

UniProt :accession O96019