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3-phosphoinositide-dependent protein kinase 2 (PDPK2)
Function:
- phosphorylates & activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 & RPS6KB1
- may play a general role in signaling processes & in development (putative)
- phosphorylated on Tyr & Ser/Thr
ATP + a protein = ADP + a phosphoprotein
Structure:
- belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, PDK1 subfamily
- contains 1 protein kinase domain
Compartment: cytoplasm, peripheral membrane (putative)
Note: could be the product of a pseudogene
General
enzyme
phosphoprotein
Properties
SIZE: entity length = 396 aa
MW = 45 kD
COMPARTMENT: cytoplasm
MOTIF: kinase domain
SITE: 55-315
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 61-69
ATP-binding site
NAME: ATP-binding site
SITE: 84-84
aspartate residue {D178}
Ser phosphorylation site {S214}
Thr phosphorylation site {T218}
Tyr phosphorylation site {Y346}
References
UniProt :accession Q6A1A2
Databases & Figures
UniProt Q6A1A2
ENZYME 2.7.11.1
RTK -> PI-3-kinase -> Akt -> ...