3-keto-steroid reductase (estradiol 17-beta-dehydrogenase 7, 17-beta-HSD 7, 17-beta-hydroxysteroid dehydrogenase 7, HSD17B7)

Function: 1) reduction of the keto group on the C-3 of sterols 2) estrogens biosynthesis 3) sterols biosynthesis 4) phosphorylated 4-alpha-methyl-5-alpha-cholest-7-en-3-beta-ol + NADP⁺ 4-alpha-methyl-5-alpha-cholest-7-en-3-one + NADPH Estradiol-17-beta + NADP⁺ estrone + NADPH Compartment: membrane Alternative splicing: named isoforms=3 Expression: - expressed in adrenal gland, liver, lung, thymus > breast, ovaries, pituitary gland, pregnant uterus, prostate, kidney, lymph node, small intestine, spinal cord, trachea > other tissues - isoform 3 is expressed in eye ciliary epithelial cells & neuroendocrine cells

General

dehydrogenase glycoprotein membrane protein phosphoprotein

Properties

SIZE: MW = 38 kD entity length = 341 aa COMPARTMENT: cellular membrane MOTIF: cofactor-binding site [8-15] COFACTOR-BOUND: NAD N-glycosylation site {N37} binding site SITE: 171-171 FOR-BINDING-OF: Substrate N-glycosylation site {N178} tyrosine residue {Y193} N-glycosylation site {N229} transmembrane domain {230-250}

Database Correlations

OMIM 606756 UniProt P56937 Pfam PF00106 ENZYME correlations

References

UniProt :accession P56937