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acetyl-Coenzyme A acyltransferase 1 (peroxisomal 3-ketoacyl CoA thiolase, peroxisomal 3-oxoacyl-Coenzyme A thiolase, beta-ketothiolase, thiolase-3, ACAA1, ACAA, PTHIO)
Function:
- lipid metabolism, fatty acid metabolism
acyl-CoA + acetyl-CoA CoA + 3-oxoacyl-CoA
Structure:
- homodimer
- belongs to the thiolase family
Compartment: peroxisome
Expression:
- peroxisomal thiolase is markedly induced (at the level of transcription) by various hypolipidemic compounds in parallel with the other two enzymes of the peroxisomal beta-oxidation system
General
3-ketoacyl CoA thiolase (beta-ketothiolase, ACAA)
Properties
SIZE: entity length = 424 aa
MW = 44 kD
COMPARTMENT: peroxisome
MOTIF: cysteine residue {C123}
histidine residue {H377}
cysteine residue {C408}
Database Correlations
OMIM correlations
UniProt P09110
Entrez Gene 30
ENZYME 2.3.1.16
References
UniProt :accession P09110