3-beta hydroxy-5-ene steroid dehydrogenase type 1; steroid delta isomerase; progesterone reductase (HSD3B1, HSDB3A)

Function: - biosynthesis of all classes of hormonal steroids - bifunctional enzyme - catalyzes oxidative conversion of delta(5)-ene-3-beta-hydroxy steroid, & oxidative conversion of ketosteroids 3-beta-hydroxy-delta(5)-steroid + NAD⁺ 3-oxo-delta(5)-steroid + NADH 3-oxo-delta(5)-steroid 3-oxo-delta(4)-steroid Structure: belongs to the 3-beta-HSD family Compartment: - endoplasmic reticulum membrane - mitochondrial membrane Expression: - placenta & skin - predominantly expressed in mammary gland tissue

General

dehydrogenase isomerase mitochondrial membrane protein

Properties

SIZE: entity length = 373 aa MW = 42 kD COMPARTMENT: mitochondrial membrane MOTIF: active site SITE: N-TERMINAL MOTIF: cofactor-binding site [5-36] FOR-BINDING-OF: NAD transmembrane domain {288-308}

Database Correlations

OMIM 109715 UniProt P14060 Pfam PF01073 Kegg hsa:3283 ENZYME correlations

References

UniProt :accession P14060