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galactosylceramide sulfotransferase; galcer sulfotransferase; 3'-phosphoadenosine-5'-phosphosulfate:galcer sulfotransferase; 3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase; cerebroside sulfotransferase (GAL3ST1, CST)
Function:
- catalyzes sulfation of membrane glycolipids
- seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety
- catalyzes synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath & of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes (putative)
- also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol & galactosyl diacylglycerol (in vitro)
- lipid metabolism; sphingolipid metabolism
3'-phosphoadenylyl sulfate + galactosylceramide = adenosine 3',5'-bisphosphate + galactosylceramidesulfate
3'-phosphoadenylyl sulfate + monogalactosylalkylacylglycerol = adenosine 3',5'-bisphosphate + monogalactosylalkylacylglycerol sulfate
Structure:
- belongs to the galactose-3-O-sulfotransferase family
Compartment:
- Golgi membrane; single-pass type 2 membrane protein (putative)
Expression:
- expressed in kidney proximal tubule, gastric mucosa
Pathology:
- expressed in adenocarcinomas
- highly expressed in renal cell carcinoma cell lines
General
glycoprotein
membrane protein
sulfotransferase
Properties
SIZE: entity length = 423 aa
MW = 49 kD
COMPARTMENT: golgi
MOTIF: transmembrane domain {15-35}
N-glycosylation site {N66}
N-glycosylation site {N312}
Database Correlations
OMIM 602300
UniProt Q99999
Pfam PF06990
Entrez Gene 9514
Kegg hsa:9514
ENZYME 2.8.2.11
References
- UniProt :accession Q99999
- GGDB; Note: glycogene database
http://riodb.ibase.aist.go.jp/rcmg/ggdb/