2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial; AKB ligase; aminoacetone synthase; glycine acetyltransferase (GCAT, KBL)

Function: - amino-acid degradation - L-threonine degradation via oxydo-reductase pathway - glycine from L-threonine: step 2/2 Acetyl-CoA + glycine CoA + 2-amino-3-oxobutanoate Cofactor: pyridoxal phosphate (putative) Structure: - belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family Compartment: - mitochondria (putative), nucleus - translocates to the nucleus upon cold & osmotic stress Expression: expressed in heart, brain, liver, pancreas > lung

General

aminotransferase ligase or synthetase mitochondrial protein

Properties

SIZE: MW = 45 kD entity length = 419 aa COMPARTMENT: mitochondria cell nucleus MOTIF: cofactor-binding site [265-265] FOR-BINDING-OF: pyridoxal phosphate

Database Correlations

OMIM 607422 UniProt O75600 Pfam PF00155 Entrez Gene 23464 Kegg hsa:23464 ENZYME 2.3.1.29

References

UniProt :accession O75600