2-acylglycerol O-acyltransferase 3 (monoacylglycerol O-acyltransferase 3, acyl CoA:monoacylglycerol acyltransferase 3, MGAT3, diacylglycerol acyltransferase 2-like protein 7, diacylglycerol O-acyltransferase candidate 7, hDC7, MOGAT3, DC7, DGAT2L7, UNQ9383/PRO34208)

Function: - catalyzes the formation of diacylglycerol from 2-monoacylglycerol & fatty acyl-CoA - catalyzes terminal step in triacylglycerol synthesis by using diacylglycerol & fatty acyl CoA as substrates. - preference toward palmitoyl-CoA & oleoyl-CoA - role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes - triacylglycerol synthesis Acyl-CoA + 2-acylglycerol CoA + diacylglycerol Acyl-CoA + 1,2-diacylglycerol CoA + triacylglycerol Kinetic parameters: - Vmax=9.3 nmol/min/mg enzyme with diacylglycerol as substrate - Vmax=22.8 nmol/min/mg enzyme with 2-monoacylglycerol as substrate Structure: belongs to the diacylglycerol acyltransferase family Compartment: - endoplasmic reticulum membrane Alternative splicing: named isoforms=3 Expression: - selectively expressed in the digestive system - expressed in the ileum > jejunum, duodenum, colon, cecum & rectum - not expressed in stomach, esophagus or trachea - expressed at very low level in liver

General

acyltransferase glycoprotein transmembrane 3 protein

Properties

SIZE: MW = 39 kD entity length = 341 aa COMPARTMENT: endoplasmic reticulum MOTIF: transmembrane domain {29-49} transmembrane domain {50-70} N-glycosylation site {N126} transmembrane domain {137-157}

Database Correlations

UniProt Q86VF5 Pfam PF03982 ENZYME correlations

References

UniProt :accession Q86VF5