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2,4-dienoyl-CoA reductase, mitochondrial (2,4-dienoyl-CoA reductase [NADPH], 4-enoyl-CoA reductase [NADPH], DECR1, DECR)
Function:
1) auxiliary enzyme of beta-oxidation
2) participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- & odd-numbered positions
3) catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA
Trans-2,3-didehydroacyl-CoA + NADP+
trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH
Structure:
- homotetramer
- belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily Commpartment: mitochondrion
Expression:
- expressed in heart, liver, pancreas > kidney >> skeletal muscle, lung
General
mitochondrial protein
oxidoreductase
Properties
SIZE: MW = 36 kD
entity length = 335 aa
COMPARTMENT: mitochondria
MOTIF: cofactor-binding site [62-94]
COFACTOR-BOUND: NAD
binding site
SITE: 157-157
FOR-BINDING-OF: Substrate
tyrosine residue {Y199}
binding site
SITE: 214-214
FOR-BINDING-OF: NAD
Database Correlations
OMIM 222745
UniProt Q16698
Pfam PF00106
ENZYME 1.3.1.34
References
- UniProt :accession Q16698
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=DECR1