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2A zinc finger protein; zinc finger E-box-binding homeobox 1; transcription factor 8; negative regulator of IL2 (ZEB1, TCF8, AREB6)
Function:
- inhibits interleukin-2 (IL-2) gene expression
- may be responsible for transcriptional repression of the IL-2 gene
- enhances or represses promoter activity of the ATP1A1 gene depending on cell type
Structure:
- belongs to the delta-EF1/ZFH-1 C2H2-type Zn+2-finger family
- contains 7 C2H2-type Zn+2 fingers
- contains 1 homeobox DNA-binding domain
Compartment: nucleus
Expression:
- expressed in heart & skeletal muscle
- not expressed in liver, spleen, or pancreas
Pathology:
- defects in ZEB1 are the cause of posterior polymorphous corneal dystrophy type 3
General
C2H2 type zinc finger protein
homeobox protein
transcription factor (TF)
Properties
SIZE: MW = 124 kD
entity length = 1124 aa
COMPARTMENT: cell nucleus
MOTIF: Zn finger C2H2-type
SITE: 170-193
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 200-222
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 240-262
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 268-292
EFFECTOR-BOUND: Zn+2
homeodomain
SITE: 581-640
Zn finger C2H2-type
SITE: 904-926
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 932-954
EFFECTOR-BOUND: Zn+2
Zn finger C2H2-type
SITE: 960-981
EFFECTOR-BOUND: Zn+2
acidic region {989-1124}
MOTIF: acidic residue (SEVERAL)
Database Correlations
OMIM 189909
MORBIDMAP 189909
UniProt P37275
Pfam PF00096
Kegg hsa:6935
References
UniProt :accession P37275