three prime repair exonuclease 2 selections

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three prime repair exonuclease 2; 3'-5' exonuclease TREX2; 26S proteasome-associated UCH37-interacting protein 1 (TREX2)

Function: - exonuclease with a preference for dsDNA with mismatched 3' termini - may play a role in DNA repair - exonucleolytic cleavage in the 3'- to 5'- direction to yield nucleoside 5'-phosphates Cofactor: - Mg⁺², required for activity - substitution with Mn+2 results in partial activity Kinetic parameters: - pH dependence: optimum pH is 7.5-8.0 Structure: - homodimer - belongs to the exonuclease superfamily, TREX family Compartment: nucleus (probable) Alternative splicing: named isoforms=2 Expression: - detected in heart, breast, prostate, skeletal muscle, testis, uterus, bone marrow, colon, small intestine, stomach & thymus Genetics: - the gene for UIP1 is either identical to or adjacent to that of TREX2 - most mRNAs that encode UIP1 also include the N-terminal part of TREX2

HAUS augmin-like complex subunit 7; 26S proteasome-associated UCH37-interacting protein 1; UCHL5-interacting protein; X-linked protein STS1769 (HAUS7, UCHL5IP, UIP1) three prime repair exonuclease 2; 3'-5' exonuclease TREX2; 26S proteasome-associated UCH37-interacting protein 1 (TREX2)

General

exodeoxyribonuclease nuclear protein

Properties

SIZE: entity length = 279 aa MW = 31 kD COMPARTMENT: cell nucleus MOTIF: active site

Database Correlations

OMIM 300370 UniProt Q9BQ50 Pfam PF00929 Entrez Gene 11219 Kegg hsa:11219 ENZYME 3.1.11.2

References

UniProt :accession Q9BQ50
NIEHS-SNPs http://egp.gs.washington.edu/data/trex2/