2'-deoxynucleoside 5'-phosphate N-hydrolase 1; deoxynucleoside 5'-phosphate N-glucosidase; c-Myc-responsive protein RCL (DNPH1, C6orf108, RCL)

Function: - catalyzes cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate & a purine or pyrimidine base - deoxyribonucleoside 5'- monophosphates containing purine bases are preferred to those containing pyrimidine bases (putative) - may play a role in the cell-cycle Structure: - monomer & homodimer (putative) - belongs to the deoxyribonucleoside 5'-monophosphate N-glycosidase family Compartment: nucleus (putative). cytoplasm Alternative splicing: named isoforms=2 Expression: - expressed at low levels in brain, colon, lung, peripheral blood leukocytes, placenta, small intestine, & thymus - expressed at high levels in heart, kidney, liver, skeletal muscle & spleen - expression: Expression is induced by ETV1 Pathology: - overexpressed in a significant proportion of breast cancers - may play a role in c-Myc-mediated transformation

General

glycosidase (glycoside hydrolase) nuclear protein phosphoprotein

Properties

SIZE: entity length = 174 aa MW = 19 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Substrate binding {24-30} MOTIF: Ser phosphorylation site {S28} binding site SITE: 39-39 FOR-BINDING-OF: Substrate binding site SITE: 104-104 FOR-BINDING-OF: Substrate Substrate binding; shared with homodimeric partner {128-130} Ser phosphorylation site {S169}

Database Correlations

UniProt O43598 Pfam PF05014 Entrez Gene 10591 Kegg hsa:10591 ENZYME 3.2.2.-

References

UniProt :accession O43598