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group XV phospholipase A2; 1-O-acylceramide synthase; ACS; LCAT-like lysophospholipase; LLPL; lysophospholipase 3; lysosomal phospholipase A2; LPLA2 (PLA2G15 LYPLA3 UNQ341/PRO540)
Function:
1) transacylase & Ca+2-independent phospholipase A2 activity
2) catalyzes the formation of 1-O-acyl-N-acetylsphingosine & concomitant release of a lysophospholipid
3) may have weak lysophospholipase activity
Structure:
- N-glycosylated
- belongs to the AB hydrolase superfamily, lipase family
Compartment: lysosome, secreted
Expression:
- expressed in heart, placenta, skeletal muscle, kidney, pancreas > spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes
General
glycoprotein
phospholipase A2; phosphatidylcholine 2-acylhydrolase (PLA2)
transferase
Properties
SIZE: entity length = 412 aa
MW = 47 kD
COMPARTMENT: lysosome
MOTIF: signal sequence {1-33}
N-glycosylation site {N99}
serine residue {S198}
N-glycosylation site {N273}
N-glycosylation site {N289}
aspartate residue {D360}
histidine residue {H392}
N-glycosylation site {N398}
Database Correlations
OMIM 609362
UniProt Q8NCC3
Pfam PF02450
Entrez Gene 23659
Kegg hsa:23659
References
UniProt :accession Q8NCC3