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1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)
Neurotoxin origionally isolated from impure preparations of heroin
Adverse effects:
- parkinsonism Mechansim of action:
- selective effects on substantia nigra dopaminergic neurons
- inhibits complex I (NADH-CoQ oxidoreductase) of the mitochondrial electron transport chain
Related
electron transport
meperidine (Demerol, Isonipecaine, Chlorbycyclen, Centralgin)
parkinsonism
General
opiate
pyridine
toxin (hazardous material, poison)
Database Correlations
PUBCHEM cid=1388
References
Lang & Lazano NEJM 339:1044-53, 1998