1-acyl-sn-glycerol-3-phosphate acyltransferase zeta (1-AGP acyltransferase 6, 1-AGPAT 6, lysophosphatidic acid acyltransferase zeta, LPAAT-zeta, AGPAT6)

Function: 1) de novo phospholipid biosynthesis, 2nd step 2) converts lysophosphatidic acid into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone 3) HXXXXD motif is essential for acyltransferase activity, binding site for phosphate moiety glycerol-3-phosphate (putative) Acyl-CoA + 1-acyl-sn-glycerol 3-phosphate CoA + 1,2-diacyl-sn-glycerol 3-phosphate Compartment: membrane Expression: - expressed in skeletal muscle, heart, testis > lung Structure: - HXXXXD motif is essential for acyltransferase activity & may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate - belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family

General

1-acyl-sn-glycerol-3-phosphate acyltransferase; 1-AGP acyltransferase; 1-AGPAT; lysophosphatidic acid acyltransferase; LPAAT; 1-acylglycerol-3-phosphate O-acyltransferase glycoprotein membrane protein

Properties

SIZE: MW = 52 kD entity length = 456 aa COMPARTMENT: cellular membrane MOTIF: signal sequence {1-37} transmembrane domain {156-176} transmembrane domain {180-200} N-glycosylation site {N247} HXXXXD {248-253} N-glycosylation site {N327} N-glycosylation site {N328} N-glycosylation site {N362}

Database Correlations

OMIM 608143 UniProt Q86UL3 Pfam PF01553 ENZYME 2.3.1.51

References

UniProt :accession Q86UL3