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17 beta-hydroxysteroid dehydrogenase-1; estradiol 17 beta-dehydrogenase 1; 20 alpha-hydroxysteroid dehydrogenase (HSD17B1)
Function:
- converts androstenedione to testosterone & estrone to estradiol
- may be two different enzymes under different control, one localized to testes
- only reversible enzyme system involved in steroid biosynthesis
- favors the reduction of estrogens & androgens
- 20-alpha-HSD activity
- estrogens biosynthesis
- favors NAD
estradiol-17-beta + NAD+/NADP+ estrone + NADH/NADPH
Structure:
- homodimer
- belongs to the short-chain dehydrogenases/reductases (SDR) family
Compartment: cytoplasm
General
17 beta-hydroxysteroid dehydrogenase (estradiol 17 beta-dehydrogenase, HSD17B1)
20-hydroxysteroid dehydrogenase or cortisone reductase
oligomerizing protein
Properties
SIZE: entity length = 328 aa
MW = 35 kD
COMPARTMENT: cytoplasm
MOTIF: cofactor-binding site [10-38]
COFACTOR-BOUND: NADP
cofactor-binding site [66-66]
COFACTOR-BOUND: NADP
binding site
SITE: 143-143
FOR-BINDING-OF: androstenedione
estrone
tyrosine residue {Y156}
cofactor-binding site [160-160]
COFACTOR-BOUND: NADP
Database Correlations
OMIM 109684
UniProt P14061
ENZYME 1.1.1.62
References
- UniProt :accession P14061
- SHMPD, The Singapore human mutation & polymorphism database
http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=HSD17B1