17 beta-hydroxysteroid dehydrogenase (estradiol 17 beta-dehydrogenase, HSD17B1)

Function: - converts androstenedione to testosterone & estrone to estradiol - this is the only reversible enzyme system involved in steroid biosynthesis Note: - may be 2 different enzymes under different control, one localized to testes

Specific

17 beta-hydroxysteroid dehydrogenase-1; estradiol 17 beta-dehydrogenase 1; 20 alpha-hydroxysteroid dehydrogenase (HSD17B1) 17 beta-hydroxysteroid dehydrogenase-2 [microsomal] (estradiol 17 beta-dehydrogenase 2, 20 alpha-hydroxysteroid dehydrogenase, HSD17B2) 17 beta-hydroxysteroid dehydrogenase-3 [testicular] (estradiol 17 beta-dehydrogenase 3, HSD17B3) 17 beta-hydroxysteroid dehydrogenase-8 (estradiol 17-beta-dehydrogenase 8, 17-beta-HSD 8, protein Ke6, Ke-6, HSD17B8, FABGL, HKE6, RING2, D6S2245E) 17-beta hydroxysteroid dehydrogenase 13 (short-chain dehydrogenase/reductase 9, HSD17B13, SCDR9, HMFN0376, UNQ497/PRO1014) 17-beta-hydroxysteroid dehydrogenase 12 (estradiol 17-beta-dehydrogenase 12, 17-beta-HSD 12, 3-ketoacyl-CoA reductase, KAR, HSD17B12) 3-OH acyl CoA dehydrogenase-2; 17-beta-hydroxysteroid dehydrogenase 10; type 2 HADH; A-beta binding alcohol dehydrogenase; endoplasmic reticulum-associated amyloid beta-peptide binding protein; short-chain type dehydrogenase/reductase (XH98G2, HSD17B10, ERAB, HADH2, SCHAD) dehydrogenase/reductase SDR family member 8 (17-beta-hydroxysteroid dehydrogenase 11, 17-beta-HSD 11, 17-beta- HSD XI, 17betaHSDXI, 17bHSD11, 17betaHSD11, retinal short-chain dehydrogenase/reductase 2, retSDR2, cutaneous T-cell lymphoma-associated antigen HD-CL-03, CTCL tumor antigen HD-CL-03, DHRS8, HSD17B11, PAN1B, PSEC0029, UNQ207/PRO233)

Properties

COMPARTMENT: smooth endoplasmic reticulum MOTIF: active site

References

UniProt :accession P14061